Identification of predictive biomarkers and dose optimization for camrelizumab combined with apatinib in the treatment of advanced hepatocellular carcinoma: a quantitative systems pharmacology approach

Authors

Zheng Jiao (ORCID: https://orcid.org/0000-0001-7999-7162)
Guihui Tu
Lin Yang
Chenyu Wang
Dandan Li
Jianxing Zhou

Institutions

Fujian Medical University (CN)
Shanghai Jiao Tong University (CN)
Shanghai Chest Hospital (CN)
Chongqing Emergency Medical Center (CN)
Fujian Provincial Cancer Hospital (CN)
Chongqing Medical University (CN)

Publication Details

Journal: Frontiers in Immunology
Published: 2026-02-17
DOI: https://doi.org/10.3389/fimmu.2026.1617227
Primary Topic: Cancer Immunotherapy and Biomarkers
Type: article
Field-Weighted Citation Impact: 0.00

Funders

National Natural Science Foundation of China
Natural Science Foundation of Fujian Province

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article

Identification of predictive biomarkers and dose optimization for camrelizumab combined with apatinib in the treatment of advanced hepatocellular carcinoma: a quantitative systems pharmacology approach

Zheng Jiao, Guihui Tu, Lin Yang, Chenyu Wang et al.

Feb 17, 2026

Frontiers in Immunology

Cancer Immunotherapy and Biomarkers

article

Identification of predictive biomarkers and dose optimization for camrelizumab combined with apatinib in the treatment of advanced hepatocellular carcinoma: a quantitative systems pharmacology approach

Zheng Jiao, Guihui Tu, Lin Yang, Chenyu Wang, Dandan Li, Jianxing Zhou

February 17, 2026article en

Abstract

No abstract available for this paper.

Frontiers in ImmunologyVol. 17

Fujian Medical University (CN), Shanghai Jiao Tong University (CN), Shanghai Chest Hospital (CN), Chongqing Emergency Medical Center (CN), Fujian Provincial Cancer Hospital (CN), Chongqing Medical University (CN)

National Natural Science Foundation of China, Natural Science Foundation of Fujian Province

Good health and well-being

Openalex Percentile: Top 51%

Cancer Immunotherapy and Biomarkers

DOI Open Access PDF OpenAlex

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