Phosphoinositide 3-kinase δ activity in patients with systemic lupus erythematosus
We describe the range of variation of PI3Kδ activity in T cells from a large cohort of patients with SLE and from healthy subjects. Our findings suggest that increased PI3Kδ activity is not associated with SLE in general, although some SLE patients exhibit a particularly strong upregulation of PIP3 levels after T-cell stimulation. This subgroup of SLE patients warrants further investigation given the promising effect of PI3Kδ inhibitors in restoring normal immune regulation.
Authors
- Elham Sadat Mirfazeli (ORCID: https://orcid.org/0000-0001-7493-2335)
- Irene E. M. Bultink (ORCID: https://orcid.org/0000-0002-5441-3420)
- Izabella Niewczas (ORCID: https://orcid.org/0000-0003-1672-5033)
- Olivier Papapietro (ORCID: https://orcid.org/0000-0001-5072-5235)
- Augusto Sánchez
- Jonathan Clark (ORCID: https://orcid.org/0009-0003-5019-5408)
- Anita Chandra
- Michel W. P. Tsang-A-Sjoe
- Klaus Okkenhaug
- Alexandre E. Voskuyl
- Shalmalee Kharkar
- Reina E. Mebius
Institutions
- Babraham Institute (GB)
- University of Cambridge (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- Center for Rheumatology (US)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-17
- DOI
- https://doi.org/10.3389/fimmu.2026.1745692
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Amsterdam University Medical Centers
- Horizon 2020 Framework Programme