S100A8/A9 inhibition reduces splenic myelopoiesis and improves outcomes after stroke
These findings identify the spleen as a key contributor to neutrophil production following stroke and suggest that targeting S100A8/A9 may mitigate myeloid skewing and improve neurological recovery.
Authors
- Grant R. Drummond (ORCID: https://orcid.org/0000-0001-8556-9738)
- Hannah X. Chu (ORCID: https://orcid.org/0000-0002-5634-6831)
- Shenpeng R. Zhang (ORCID: https://orcid.org/0000-0003-1821-750X)
- A. Al-sharea
- Prabhakara R. Nagareddy (ORCID: https://orcid.org/0000-0002-0294-641X)
- Andrew J. Murphy (ORCID: https://orcid.org/0000-0001-6747-0355)
- Man K.S. Lee
- Thiruma V. Arumugam (ORCID: https://orcid.org/0000-0002-3377-0939)
- Samoda Rupasinghe
- Hyun Ah Kim (ORCID: https://orcid.org/0000-0002-3175-9218)
- Sung-Chun Tang
- C G Sobey
Institutions
- Baker Heart and Diabetes Institute (AU)
- The University of Melbourne (AU)
- La Trobe University (AU)
- National Taiwan University Hospital (TW)
- University of Oklahoma Health Sciences Center (US)
- Monash University (AU)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-17
- DOI
- https://doi.org/10.3389/fimmu.2026.1768647
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.00