Association of perioperative patient characteristics, intraoperative fluid management, and vasopressors with anastomotic leakage after Ivor-Lewis esophagectomy—a single center retrospective cohort

Preoperative P2Y12 therapy and intraoperative vasopressin use were independently associated with AL after esophagectomy. P2Y12 therapy may reflect high-risk vascular biology, while vasopressor selection represents a modifiable factor. These findings warrant validation but support the careful selection of vasopressors and enhanced monitoring in P2Y12 patients.