Astrocytic regulation in hippocampal CA2 mediates the impact of sleep deprivation on spatial working memory
Metabolic dysfunction and calcium signaling abnormalities in astrocytes of the hippocampal CA2 region are key mechanisms underlying spatial memory impairment caused by CSD. Activation of CA2 astrocytes can restore memory function, providing a novel therapeutic target for cognitive deficits associated with sleep disorders.
Authors
- Hoiyin Cheung
- Yunshuang Ye (ORCID: https://orcid.org/0000-0002-4463-4334)
- Yi-Xiang Wang (ORCID: https://orcid.org/0000-0002-4021-4228)
- Jun Fang
- Jingang He
Institutions
- Shanghai Jiao Tong University (CN)
- Harbin Institute of Technology (CN)
- Ruijin Hospital (CN)
- Songjiang District Central Hospital (CN)
Publication Details
- Journal
- Frontiers in Systems Neuroscience
- Published
- 2026-02-17
- DOI
- https://doi.org/10.3389/fnsys.2026.1744203
- Primary Topic
- Memory and Neural Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China