Impact of single vs. dual local anaesthetic regimen on the efficacy and safety of percutaneous stellate ganglion block for electrical storm: new insights from the STAR study

The combination of two local anaesthetics for PSGB is significantly associated with a greater likelihood of early and complete ventricular arrhythmia suppression in patients with electrical storm. Despite the need for randomized ad-hoc trials, the dual-LA regimen represents an optimization strategy for PSGB, offering enhanced efficacy without an increased risk of major complications.

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Publication Details

Journal
European Heart Journal - Cardiovascular Pharmacotherapy
Published
2026-02-15
DOI
https://doi.org/10.1093/ehjcvp/pvag011
Primary Topic
Cardiac Arrhythmias and Treatments
Type
article
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article

Impact of single vs. dual local anaesthetic regimen on the efficacy and safety of percutaneous stellate ganglion block for electrical storm: new insights from the STAR study

Francesco Notaristefano, Domenico Tavella, Giulio Boggian, Claudia Carassia et al.
European Heart Journal - Cardiovascular Pharmacotherapy
Cardiac Arrhythmias and Treatments
article

Impact of single vs. dual local anaesthetic regimen on the efficacy and safety of percutaneous stellate ganglion block for electrical storm: new insights from the STAR study

Francesco Notaristefano, Domenico Tavella, Giulio Boggian, Claudia Carassia, Giacomo Mugnai, Matteo D’Ammando, Giuseppe Dattilo, N Tanese, Vito Joseph Sgromo, R Falcetti, Simone Persampieri, Laura Frigerio, Veronica DUSI, Federico Migliore, Claudia Colombo, Alessandro Paoletti Perini, Giuseppe D’Angelo, Leila Ulmanova, Antonio Toscano, Giulia Girardengo, Edoardo Gandolfi, Enrica Talini, Giuseppe Sangiorgi, Lorenzo Spighi, Arianna Morena, Enrico Baldi, Simone Frea, Tommaso Sanna, M Casula, Enrico Chieffo, Giulio Conte, Alessia Currao, Marco Scaglione, Simone Savastano, Sara Bendotti, Pietro Rossi, Francesca Romana Gentile, Francesco De Sensi, Pasquale Crea, Nicolò Sisti, Silvia Miette Pontremoli, Valeria Carinci, Raimondo Pittorru, Gabriele Dell’Era, Filippo Angelini, Roberto Primi, Gianmarco Iannopollo, Nastasia Mancini, Gaetano Maria De Ferrari, Carol Gravinese, G Patti
article en

Abstract

The combination of two local anaesthetics for PSGB is significantly associated with a greater likelihood of early and complete ventricular arrhythmia suppression in patients with electrical storm. Despite the need for randomized ad-hoc trials, the dual-LA regimen represents an optimization strategy for PSGB, offering enhanced efficacy without an increased risk of major complications.

European Heart Journal - Cardiovascular Pharmacotherapy
University of Rome Tor Vergata (IT), University of Verona (IT), Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT), University of Padua (IT), Vita-Salute San Raffaele University (IT), University of Pavia (IT), Eagle Ridge Hospital (CA), Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT), Fondazione Ricerca Molinette (IT), Ospedale Maggiore Carlo Alberto Pizzardi (IT), Azienda Sanitaria di Firenze (IT), Azienda Sanitaria Locale di Asti (IT), CTO Andrea Alesini (IT), Azienda Ospedaliero Universitaria Maggiore della Carita (IT), Azienda Ospedaliera Sant'Andrea (IT), Department of Medical Sciences (BY), IRCCS Ospedale San Raffaele (IT), Ospedale Misericordia - Grosseto (IT), Azienda Ospedaliera Ospedale Maggiore (IT), Policlinico San Matteo Fondazione (IT), Azienda Usl Toscana Centro (IT), Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo (IT), Azienda Ospedaliera G. Brotzu (IT), Misericordia University (US)
Good health and well-being
Openalex Percentile: Top 55%
Cardiac Arrhythmias and Treatments
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