Single-cell atlas reveals a pro-metastatic RELB+ neutrophil-myeloid subset underlying lymph node metastasis in EGFR-wildtype LUAD
The study highlights a pro-metastatic ELANE + neutrophil subpopulation, with RELB acting as its primary transcriptional regulator. The RELB signature may serve as a biomarker for prognosis and treatment response prediction, indicating a potential target for precision treatment in EGFR wildtype LUAD.
Authors
- Heng Zhang (ORCID: https://orcid.org/0000-0002-0103-2173)
- Liyao Lin
- Yutao Pang
- Fasheng Li
- Yang, Xiao, Lucien
- Dong Wu
- Ang Li
Institutions
- Affiliated Hospital of Guangdong Medical College Hospital (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-02-17
- DOI
- https://doi.org/10.3389/fcell.2026.1766211
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00