Alleviation of high-fat diet-induced lipid metabolism disorders: role of quinoa peptides in reducing high-activity BSH-producing gut microbiota abundance and modulating BA-FXR/TGR5 signaling

These findings demonstrate that QPep modulate gut microbiota-BAs signaling to restore lipid homeostasis, highlighting their potential as a dietary intervention for the prevention and management of obesity-related metabolic disorders.

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Publication Details

Journal
Journal of Advanced Research
Published
2026-02-01
DOI
https://doi.org/10.1016/j.jare.2026.02.040
Primary Topic
Gut microbiota and health
Type
article
Field-Weighted Citation Impact
0.00
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article

Alleviation of high-fat diet-induced lipid metabolism disorders: role of quinoa peptides in reducing high-activity BSH-producing gut microbiota abundance and modulating BA-FXR/TGR5 signaling

Zhi Feng, Tianliang Wu, Yiju Li, Siwang Peng et al.
Journal of Advanced Research
Gut microbiota and health
article

Alleviation of high-fat diet-induced lipid metabolism disorders: role of quinoa peptides in reducing high-activity BSH-producing gut microbiota abundance and modulating BA-FXR/TGR5 signaling

Zhi Feng, Tianliang Wu, Yiju Li, Siwang Peng, Yuanrong Tuo, Long Ding, Zhiqing Lin, Jianping Wu, Yuyu Zhang, Zhigang Liu, Xuebo Liu, Yu Xiang Zhang, Ting Cai, Tianqi Liu, Haixi You
article en

Abstract

These findings demonstrate that QPep modulate gut microbiota-BAs signaling to restore lipid homeostasis, highlighting their potential as a dietary intervention for the prevention and management of obesity-related metabolic disorders.

Journal of Advanced Research
University of Alberta (CA), North West Agriculture and Forestry University (CN), Shaanxi Normal University (CN), Northwest A&F University (CN)
Zero hunger
Openalex Percentile: Top 52%
Gut microbiota and health
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