Analysis of treatment outcome variations in infantile epileptic spasms syndrome
The prognosis for IESS remains challenging, with treatment responses closely tied to etiology. Children with genetic etiologies demonstrate poorer responses to ACTH and other ASMs. However, ACTH combination with vigabatrin may improve treatment outcomes in some cases. Our findings suggest that ACTH treatment may not exert a substantial influence on long-term EEG outcomes in children with IESS.
Authors
- Xueyi Rao
- Jing Ye Gan (ORCID: https://orcid.org/0000-0002-7804-7963)
- Jianjun Wang (ORCID: https://orcid.org/0000-0003-4286-6630)
- Yajun Shen
- Xue Gong
- Jia Zhang
- Xiaoqian Wang
- Jun Chen
Institutions
- Sichuan University (CN)
- West China Second University Hospital of Sichuan University (CN)
- Shanxi Provincial Children's Hospital (CN)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2026-02-17
- DOI
- https://doi.org/10.3389/fneur.2026.1749636
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- National Natural Science Foundation of China