Effects of T2-high asthma heterogeneity and inhaled corticosteroid on airway and metabolic profiles: A multi-omic approach
The airway local microenvironment and systemic metabolic profiles of treatment-naive T2-high asthma patients were distinctly different from those of healthy individuals. Limited heterogeneity was observed among patients stratified in terms of T2-inflammatory burden. ICS altered the airway microenvironment and rectified the lipid/arachidonic acid metabolic dysregulation. However, ICS effects varied across various T2-high subgroups.
Authors
- Yuting Duan (ORCID: https://orcid.org/0000-0003-4113-5000)
- Wei Yang (ORCID: https://orcid.org/0000-0003-2945-2898)
- Xi Wang (ORCID: https://orcid.org/0000-0002-5974-6363)
- Yuxing Wang (ORCID: https://orcid.org/0000-0003-3079-5572)
- Zhixia Gu
- Kewu Huang
- Chuan Song
- Ronghua Jin
- Tingting Liu
- Yuanyuan Zhang
Institutions
- Capital Medical University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- Beijing Anding Hospital (CN)
- Beijing Ditan Hospital (CN)
- Beijing Tsinghua Chang Gung Hospital (CN)
Publication Details
- Journal
- Journal of Translational Internal Medicine
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1515/jtim-2026-0001
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00