Extracellular vesicles ameliorate intrauterine adhesion through Nrf2/GPX4-mediated ferroptosis suppression
This study identifies EVs as central functional components through which L. crispatus NCU-28 exerts anti-inflammatory and anti-fibrotic effects, and it delineates the mechanistic role of EVs in ameliorating IUA. These findings provide a basis for developing innovative probiotic EV-based treatment strategies.
Authors
- ChengRui LIU
- Qinghui Li
- Zhaoxia Liu (ORCID: https://orcid.org/0009-0008-5448-7324)
- Tingtao Chen
- Ruiyan Xu
- Xuan Zhang (ORCID: https://orcid.org/0000-0001-6274-0598)
- Min Ji
- Yi Ju Li
- Qin Xiao
- Leiping Ding
- Jing Wei
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Second Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.jare.2026.02.035
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00