A low dose of the γ‐secretase inhibitor DAPT improves learning and memory by regulating the Na <sub>V</sub> 1.6/Notch axis in C57BL/6 male mice
Low-dose DAPT improved cognitive function in C57BL/6 male mice, by modulating the Na<sub>V</sub> 1.6/Notch axis and enhancing neurogenesis, indicating its potential as a therapeutic strategy for Alzheimer's-related cognitive decline.
Authors
- Qi‐Fa Li
- Ao‐Ran Sui (ORCID: https://orcid.org/0009-0006-3205-0944)
- Yifan Zhao (ORCID: https://orcid.org/0000-0001-8986-9164)
- Yue‐Lin Huang
- Ying‐Zi Wang
- Yue Kong (ORCID: https://orcid.org/0000-0003-0559-113X)
- Xiaoqin Luo (ORCID: https://orcid.org/0000-0002-3572-3909)
- Muhammad Khalid Iqbal
- Jincheng Lu
- Kabir Ahmad
- Bakhtawar Khan
- Qing‐Da Shi
- Xiao‐Dong Chi
- Shao Li
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1111/bph.70369
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00