Ethnic‐specific effects of the <i>LILRB2–LILRB5</i> locus and newly identified risk loci for Alzheimer's disease in the East Asian population
The results establish LILRB2-LILRB5 as a cross-ancestry AD-associated locus with ethnic-specific genetic mechanisms and reveal new susceptibility loci, extending the understanding of the genetic etiology of AD.
Authors
- Joyce Ruifen Chong (ORCID: https://orcid.org/0000-0002-2869-0096)
- Masataka Kikuchi (ORCID: https://orcid.org/0000-0002-9562-841X)
- Han Cao (ORCID: https://orcid.org/0000-0001-9992-9108)
- Nancy Y. Ip
- Ziyun Xu
- Timothy C Y Kwok
- Vincent C. T. Mok
- Maryam Shoai
- Linda C. W. Lam
- Kin Ying Boniface MOK
- Hiu Yi Wong
- Ronnie M. N. Lo
- Elaine Y. L. Cheng
- Bonnie W. Y. Wong
- Akinori Miyashita
- Fanny C. F. Ip
- Christopher Chen
- Takeshi Ikeuchi
- John Hardy
- Andrew L. T. Chan
- Xiaopu Zhou
- Alzheimer's Disease Neuroimaging Initiative
- Japanese Alzheimer's Disease Neuroimaging Initiative
- Yu Chen
Institutions
- National University of Singapore (SG)
- Chinese University of Hong Kong (HK)
- HKUST Shenzhen Research Institute (CN)
- Institute for Neurodegenerative Disorders (US)
- UK Dementia Research Institute (GB)
- Shenzhen Institutes of Advanced Technology (CN)
- National University Health System (SG)
- National Hospital for Neurology and Neurosurgery (GB)
- Queen Elizabeth Hospital (CN)
- University College London (GB)
- Niigata University (JP)
- University of Hong Kong (HK)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/alz.71219
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Foundation for the National Institutes of Health
- Alzheimer's Association
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Biogen
- Fidelity Foundation
- Meso Scale Diagnostics
- Alzheimer's Disease Neuroimaging Initiative
- BioClinica
- Novartis Pharmaceuticals Corporation
- Japan Agency for Medical Research and Development
- Northern California Institute for Research and Education
- University Grants Committee
- Innovation and Technology Commission
- Eisai
- Hong Kong University of Science and Technology
- Innovation and Technology Fund
- Servier
- H. Lundbeck A/S
- IXICO
- National Institutes of Health
- Genentech
- Canadian Institutes of Health Research
- Medical Research Council
- National Medical Research Council
- Japan Society for the Promotion of Science
- National Bioscience Database Center