CircNF1 promotes gastric cancer metastasis by stabilizing HMGA2 mRNA through IGF2BP1 interaction
Our findings demonstrate that ZNF460-mediated upregulation of circNF1 drives GC metastasis by acting as a molecular scaffold to interact with IGF2BP1 and stabilize HMGA2 mRNA. This study not only elucidates a novel regulatory axis in GC metastasis but also identifies circNF1 as a promising prognostic biomarker and potential therapeutic target for the treatment of metastatic GC.
Authors
- Y. C. Ge
- Zheng Wang (ORCID: https://orcid.org/0000-0003-4873-505X)
- George Zhang (ORCID: https://orcid.org/0000-0003-2073-7109)
- Cheng Guo (ORCID: https://orcid.org/0000-0002-1219-1268)
- Yingying Sun
- Zhiyu Xia
Institutions
- Tongji University (CN)
- Xinjiang Medical University (CN)
- Second Hospital of Shandong University (CN)
- Shanghai East Hospital (CN)
- Tongji Hospital (CN)
- Qilu Hospital of Shandong University (CN)
- Second Affiliated Hospital of Xinjiang Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-17
- DOI
- https://doi.org/10.3389/fimmu.2026.1767319
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00