Clinical toxicity of daridorexant: a retrospective analysis of poison centre data

While daridorexant appears safe when taken alone, clinicians should remain vigilant in polypharmacy scenarios involving central nervous system depressants. Further studies are needed to confirm sex-related differences and refine risk stratification in overdose management.

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Publication Details

Journal
Clinical Toxicology
Published
2026-02-17
DOI
https://doi.org/10.1080/15563650.2026.2617481
Primary Topic
Luminescence and Fluorescent Materials
Type
article
Field-Weighted Citation Impact
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article

Clinical toxicity of daridorexant: a retrospective analysis of poison centre data

A. Descatha, Ingrid Blanc-Brisset, Marion Evrard, A. Nardon et al.
Clinical Toxicology
Luminescence and Fluorescent Materials
article

Clinical toxicity of daridorexant: a retrospective analysis of poison centre data

A. Descatha, Ingrid Blanc-Brisset, Marion Evrard, A. Nardon, J. Langrand, C. Paradis, M. Labadie, M. Legeay, Marc Boyé, Katharina von Fabeck, Nicolas Delcourt, Marion Legeay, Fanny Pélissier, Gaël Le Roux, Emmanuel Puskarczyk, Patrick Nisse, G. Balice, A. Gouraud, Weniko Caré, Anne Garat, Ramy Azzouz, Céline Moulut, Florent Battefort, Jean-Paul Boudsocq, Cécile Chevallier, Coralie Bragança, Hervé Laborde-Casterot, Fabien Genestier, Nicolas Simon, Romain Torrents, French PCC Research Group
article en

Abstract

While daridorexant appears safe when taken alone, clinicians should remain vigilant in polypharmacy scenarios involving central nervous system depressants. Further studies are needed to confirm sex-related differences and refine risk stratification in overdose management.

Clinical Toxicology
Centre Hospitalier Universitaire de Lille (FR), Hôpital Laveran (FR), Centre Hospitalier Régional et Universitaire de Nancy (FR), Hospices Civils de Lyon (FR), Hôpital Fernand-Widal (FR), Hôpital Pellegrin (FR), Centre Hospitalier Universitaire d'Angers (FR), Hôpital Sainte-Marguerite (FR), Institut de Neurosciences de la Timone (FR), Hôpital Purpan (FR)
Good health and well-being
Openalex Percentile: Top 53%
Luminescence and Fluorescent Materials
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Clinical toxicity of daridorexant: a retrospective analysis of poison centre data — A. Descatha, Ingrid Blanc-Brisset, et al. · Clinical Toxicology (2026) | TGRS Research Map | TGRS