<scp>SIX2</scp> ‐Mediated Microglial <scp>M2</scp> Polarization and Exosomal <scp>miR</scp> ‐3470b Delivery Protect Dopaminergic Neurons in Parkinson's Disease
SIX2 promotes microglial M2 polarization via the DDIT4/mTOR/autophagy axis and mediates neuroprotection through exosomal miR-3470b targeting of GREM1/TGF-β signaling, revealing novel therapeutic targets for PD immunotherapy.
Authors
- Guojing Sun (ORCID: https://orcid.org/0000-0002-4178-2964)
- Jin Gao
- Xia‐yin Cao
- Xin‐xing Huang
- Yu‐xin Ye
- Jia‐shuo Kan
Institutions
- Xuzhou Medical College (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/cns.70756
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00