Chlorpromazine activates cGAS-STING signaling and reprograms the immune response in glioblastoma
This study uncovers that CPZ exerts a previously unrecognized anti-cancer immunomodulatory activity, remodeling the immune microenvironment and enhancing the anti-tumor immune response. By overcoming TMZ resistance, CPZ not only exerts a direct anti-neoplastic effect, but also sensitizes GBM cells to standard therapy.
Authors
- Marco G. Paggi (ORCID: https://orcid.org/0000-0002-9445-442X)
- Luisa Gesualdi
- Barbara Ascione
- Claudia Abbruzzese (ORCID: https://orcid.org/0000-0003-3301-9421)
- Lucrezia Gambardella (ORCID: https://orcid.org/0000-0003-3899-5958)
- Francesca Paolini (ORCID: https://orcid.org/0000-0002-7384-6248)
- Giulia Fanelli
- Andrea Sacconi
- Paola Matarrese
Institutions
- Istituto Superiore di Sanità (IT)
- National Cancer Institute (MY)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-17
- DOI
- https://doi.org/10.3389/fimmu.2026.1743232
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Ministero della Salute
- Istituto Superiore di Sanità
- Associazione Italiana per la Ricerca sul Cancro