Endogenous sex hormones, sex hormone-binding globulin, and muscle health: insights into sarcopenia and sarcopenic obesity from the Women’s Health Initiative

Among postmenopausal women, higher SHBG concentrations at baseline were associated with lower lean body mass and a higher odds of sarcopenia, while higher free estradiol and free testosterone concentrations were associated with a lower odds of sarcopenia.

Authors

Carolyn Crandall (ORCID: https://orcid.org/0000-0001-9441-0198)
Amar Osmancevic (ORCID: https://orcid.org/0000-0002-2774-0194)
Richard O. Burney (ORCID: https://orcid.org/0000-0001-7344-7805)
Bledar Daka
Jane A. Cauley
Matthew Allison
Joseph C. Larson
Aladdin H. Shadyab

Institutions

University of California, Los Angeles (US)
University of Pittsburgh (US)
UC San Diego Health System (US)
University of Alabama at Birmingham (US)
University of California San Diego (US)
Fred Hutch Cancer Center (US)
Human Longevity (United States) (US)
University of Gothenburg (SE)

Publication Details

Journal: Menopause The Journal of The North American Menopause Society
Published: 2026-02-17
DOI: https://doi.org/10.1097/gme.0000000000002734
Primary Topic: Nutrition and Health in Aging
Type: article
Field-Weighted Citation Impact: 0.00

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article

Endogenous sex hormones, sex hormone-binding globulin, and muscle health: insights into sarcopenia and sarcopenic obesity from the Women’s Health Initiative

Carolyn Crandall, Amar Osmancevic, Richard O. Burney, Bledar Daka et al.

Feb 17, 2026

Menopause The Journal of The North American Menopause Society

Nutrition and Health in Aging

article

Endogenous sex hormones, sex hormone-binding globulin, and muscle health: insights into sarcopenia and sarcopenic obesity from the Women’s Health Initiative

Carolyn Crandall, Amar Osmancevic, Richard O. Burney, Bledar Daka, Jane A. Cauley, Matthew Allison, Joseph C. Larson, Aladdin H. Shadyab

February 17, 2026article en

Abstract

Among postmenopausal women, higher SHBG concentrations at baseline were associated with lower lean body mass and a higher odds of sarcopenia, while higher free estradiol and free testosterone concentrations were associated with a lower odds of sarcopenia.

Menopause The Journal of The North American Menopause Society

University of California, Los Angeles (US), University of Pittsburgh (US), UC San Diego Health System (US), University of Alabama at Birmingham (US), University of California San Diego (US), Fred Hutch Cancer Center (US), Human Longevity (United States) (US), University of Gothenburg (SE)

Gender equality

Openalex Percentile: Top 50%

Nutrition and Health in Aging

DOI Source OpenAlex

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Endogenous sex hormones, sex hormone-binding globulin, and muscle health: insights into sarcopenia and sarcopenic obesity from the Women’s Health Initiative — Carolyn Crandall, Amar Osmancevic, et al. · Menopause The Journal of The North American Menopause Society (2026) | TGRS Research Map | TGRS