Mass spectrometry-based multi-omics analysis elucidates immune microenvironmental characteristics and the risk of distant metastasis in N1c colorectal cancer
We assessed the protein expression profiles and pathway characteristics of N1c CRC. The model developed based on TDRGs, effectively predicted DFS and immunotherapy response, supporting precision treatment and staging system optimization. PLOD1's role in ECM remodeling and CRC cell migration and invasion suggests its potential as a prognostic biomarker and therapeutic target.
Authors
- Haobo Jin
- Y. Chen (ORCID: https://orcid.org/0009-0008-5290-4526)
- Qiongying Zhang
- Yating Zheng
- Yunfei Liu (ORCID: https://orcid.org/0000-0001-9327-2037)
- Hangjia Xu
- C. Zheng
- Binbin Ou
- Xiaodong Zhang
- Baiwang Zhu
- Yifei Pan
- Zihan Wang
- Peng Li
Institutions
- Central South University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Hangzhou Hospital of Traditional Chinese Medicine (CN)
- Third Xiangya Hospital (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-17
- DOI
- https://doi.org/10.3389/fimmu.2026.1590042
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00