Antitumor effects of STING agonists on nervous system tumors via tumor-intrinsic STING-STAT1-mediated HMGN2 expression
This study clarified the mechanism underlying the potent antitumor activity of SR-717 in nervous system tumors through activation of the STING-STAT1-HMGN2 signaling pathway and demonstrated that SR-717 has superior efficacy compared to E7766. In addition, HMGN2 was shown to exhibit translational potential as a prognostic biomarker for patient survival.
Authors
- Tiance Wang
- Qian Mei (ORCID: https://orcid.org/0000-0003-4648-7232)
- Jiejie Liu (ORCID: https://orcid.org/0009-0006-5442-6471)
- Meixia Chen (ORCID: https://orcid.org/0009-0000-3483-4394)
- ZhengFan JIANG
- Qianyi Ming
- Weidong Han
- Wei Chen
- Yan Zhang
- Yulin Jia
- Runjia Fan
- Zijian Lv
Institutions
- Peking University (CN)
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- Cancer Biology and Medicine
- Published
- 2026-02-16
- DOI
- https://doi.org/10.20892/j.issn.2095-3941.2025.0326
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00