Polygenic Risk for Cardiometabolic and Cardiovascular Disease in a Multiethnic Cohort of Breast Cancer Survivors
Although there may be potential value of PGS in predicting the risk for CMD and CVD events in women with histories of breast cancer, current PGS performance is limited. This work highlights the need to develop de novo PGS in breast cancer patients and to include ancestrally diverse patient populations.
Authors
- Song Yao
- Isaac Joshua Ergas (ORCID: https://orcid.org/0000-0002-3187-9754)
- Haiyang Sheng (ORCID: https://orcid.org/0000-0002-7014-3555)
- Eileen Rillamas‐Sun (ORCID: https://orcid.org/0000-0002-8637-0437)
- Alexa Zimbalist
- Jennifer Delmerico (ORCID: https://orcid.org/0000-0001-5475-5829)
- Peter N. Fiorica (ORCID: https://orcid.org/0000-0002-1001-1518)
- Marilyn L. Kwan (ORCID: https://orcid.org/0000-0001-8863-3950)
- Janise M. Roh (ORCID: https://orcid.org/0000-0002-8615-4320)
- Dawn L. Hershman (ORCID: https://orcid.org/0000-0001-8807-153X)
- Jamal S. Rana
- Lawrence H. Kushi
- Valerie S. Lee
- Heather Greenlee
- Christine B. Ambrosone
- Richard K. Cheng
- Cecile A. Laurent
- Mai Nguyen-Huynh
- Carlos Iribarren
- Qianqian Zhu
Institutions
- Roswell Park Comprehensive Cancer Center (US)
- Kaiser Permanente (US)
- Columbia University Irving Medical Center (US)
- Kaiser Permanente Oakland Medical Center (US)
- Fred Hutch Cancer Center (US)
- Kaiser Permanente Walnut Creek Medical Center (US)
Publication Details
- Journal
- JACC CardioOncology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.jaccao.2025.10.004
- Citations
- 1
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 30.07