Early empiric antibiotic exposure affects gut microbiota development of very preterm infants

This multicenter cohort study investigates the impact of early empiric antibiotic exposure in very preterm infants on the gut microbiota during the first month of life. It includes a unique control group of infants without any antibiotic exposure. It shows both short and long early empiric antibiotic exposure affects the gut microbiota diversity, composition, and community type during the first month of life. Efforts aimed at reducing the initiation of early empirical antibiotic treatment in very preterm infants with suspected early-onset sepsis may help mitigate disruptions to the developing gut microbiota.

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Publication Details

Journal
Pediatric Research
Published
2026-02-17
DOI
https://doi.org/10.1038/s41390-026-04778-y
Primary Topic
Neonatal and Maternal Infections
Type
article
Field-Weighted Citation Impact
0.00

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article

Early empiric antibiotic exposure affects gut microbiota development of very preterm infants

Anna M. Malinowska, C. Belzer, Hendrik J. Niemarkt, V. Cossey et al.
Pediatric Research
Neonatal and Maternal Infections
article

Early empiric antibiotic exposure affects gut microbiota development of very preterm infants

Anna M. Malinowska, C. Belzer, Hendrik J. Niemarkt, V. Cossey, Nathalie J Oldenburger, Marlou M A Kouwenberg-Raets, Kelly Klomp, Esther d’Haens, Nina M. Frerichs, T De Meij, Aranka J. van Wesemael, Willem P. de Boode, Christian V. Hulzebos, On behalf of the Dutch MIRECA Collaborative Group, Anton H. van Kaam, Marijn J. Vermeulen, Chris H. P. van den Akker, Daniel C. Vijlbrief, Rimke R. de Kroon
article en

Abstract

This multicenter cohort study investigates the impact of early empiric antibiotic exposure in very preterm infants on the gut microbiota during the first month of life. It includes a unique control group of infants without any antibiotic exposure. It shows both short and long early empiric antibiotic exposure affects the gut microbiota diversity, composition, and community type during the first month of life. Efforts aimed at reducing the initiation of early empirical antibiotic treatment in very preterm infants with suspected early-onset sepsis may help mitigate disruptions to the developing gut microbiota.

Pediatric Research
Radboud University Nijmegen (NL), Maastricht University Medical Centre (NL), Radboud University Medical Center (NL), University Medical Center Utrecht (NL), Emma Kinderziekenhuis (NL), Amalia Kinderziekenhuis (NL), Beatrix Kinderziekenhuis (NL), Máxima Medisch Centrum (NL), Erasmus MC - Sophia Children’s Hospital (NL), Isala (NL), Amsterdam University Medical Centers (NL), Wilhelmina Children's Hospital (NL), Eindhoven University of Technology (NL), Wageningen University & Research (NL), KU Leuven (BE)
Danone
Openalex Percentile: Top 55%
Neonatal and Maternal Infections
DOIOpen Access PDFOpenAlex
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