Effectiveness and Safety of Empirical Antifungal Strategies in Critically Ill, Non-Neutropenic Patients: A Multi-Center Observational Study

Fluconazole-based EAFT was associated with lower mortality rates compared to other antifungal agents. However, with a confirmed fungal infection rate of only 7.41%, these findings suggest that current patient selection for EAFT is suboptimal. The high overall mortality, coupled with the low infection confirmation rate, underscores the need for improved risk stratification tools to ensure the judicious use of antifungals in this critically ill population.