Comparative analysis of oncologic outcomes: kidney-sparing surgery versus radical nephroureterectomy for localized high-risk upper tract urothelial carcinoma

KSS exhibits similar oncological efficacy as RNU in managing localized high-risk UTUC, with less damage to patients and benefit of better preservation of renal function. Adverse factors such as elevated preoperative creatinine levels, advanced pathological stage, and increased intraoperative blood loss may correlate with inferior overall survival. Additional prospective research is necessary to confirm the validity of our findings.