A putative prognostic model for lung adenocarcinoma based on crotonylation-related genes by bioinformatics and experimental verification
This study proposes a putative prognostic model based on CRGs for LUAD outcome prediction. The hub gene FAM83A may facilitate lung cancer cell growth by regulating glycolysis via PKM2 and LDHA, offering a novel theoretical foundation and a potential target for prognostic assessment and targeted therapy in LUAD patient.
Authors
- Baixiang CUI
- Wenting Wang (ORCID: https://orcid.org/0000-0003-1935-2420)
- Xiaoyu Yuan (ORCID: https://orcid.org/0000-0003-1099-0311)
- Qi Yuan
- Zihan Zhen
- Qing Cui
- Xueqing Song
- Haoyue Li
- Yong Liu
Institutions
- Jiamusi University (CN)
- Xinjiang Medical University (CN)
- Mudanjiang Medical University (CN)
- Second Affiliated Hospital of Xinjiang Medical University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-02-17
- DOI
- https://doi.org/10.3389/fcell.2026.1639773
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00