CRISPR/Cas9 Screens Implicate RARA and SPNS1 in Doxorubicin Cardiotoxicity
Our study identified numerous drug-gene interactions that illuminate mechanisms underlying DOX-induced cardiotoxicity and provide a technical framework for future functional genomics screens to nominate therapeutic targets and genetic biomarkers.
Authors
- Wenjian Lv
- Kiran Musunuru (ORCID: https://orcid.org/0000-0003-3298-0368)
- Yeng Shao
- Atsushi Hoshino (ORCID: https://orcid.org/0000-0002-4015-1319)
- Zoltan Arany
- Chris McDermott-Roe
Institutions
- Kyoto Prefectural University of Medicine (JP)
- University of Pennsylvania (US)
Publication Details
- Journal
- JACC CardioOncology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.jaccao.2026.01.003
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00