Controlled human pneumococcal infection in the Netherlands: Colonisation, antibody responses and the impact of viral co-infection
Colonisation rates were comparable to studies in other populations. Colonisation induced systemic and mucosal antibody responses, while viral co-infection increased symptom burden. This controlled infection study demonstrates feasibility and safety, and establishes a platform for vaccine evaluation and pneumococcal-viral interaction studies.
Authors
- Lucille F. van Beek (ORCID: https://orcid.org/0000-0002-7126-2580)
- Marc J. Eleveld (ORCID: https://orcid.org/0000-0001-7454-018X)
- Janeri Fröberg (ORCID: https://orcid.org/0000-0002-1487-3633)
- Suzanne E.T. Comans
- Hans de Graaf (ORCID: https://orcid.org/0000-0001-8055-8749)
- Christa E. van der Gaast-de Jongh
- Jean-Luc Murk
- Verweij Jj
- Matthew B.B. McCall
- Koen Totté
- Benjamin Mordmüller
- Dimitri A. Diavatopoulos
- Daniela M. Ferreira
- Marien I. de Jonge
Institutions
- Radboud University Nijmegen (NL)
- Liverpool School of Tropical Medicine (GB)
- Radboud University Medical Center (NL)
- Radboud Institute for Molecular Life Sciences (NL)
- Elisabeth-TweeSteden Ziekenhuis (NL)
Publication Details
- Journal
- Journal of Infection
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1016/j.jinf.2026.106704
- Primary Topic
- Pneumonia and Respiratory Infections
- Type
- article
- Field-Weighted Citation Impact
- 0.00