B-cell peptide epitopes as diagnostic targets for Q fever in sheep

Although single peptides lacked discriminatory power, multi-epitope combinations reached acceptable accuracy and may be used as a complementary tool for commercial ELISAs. However, larger bioinformatic approaches and validation studies are required to identify specific peptides of high diagnostic accuracy.

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Publication Details

Journal
Frontiers in Microbiology
Published
2026-02-17
DOI
https://doi.org/10.3389/fmicb.2026.1751544
Primary Topic
Vector-borne infectious diseases
Type
article
Field-Weighted Citation Impact
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article

B-cell peptide epitopes as diagnostic targets for Q fever in sheep

Tamara Kozytska, Claudia Gerlach, Maksym Danchenko, Hanka Brangsch et al.
Frontiers in Microbiology
Vector-borne infectious diseases
article

B-cell peptide epitopes as diagnostic targets for Q fever in sheep

Tamara Kozytska, Claudia Gerlach, Maksym Danchenko, Hanka Brangsch, Heinrich Neubauer, Gabriela Flores‐Ramírez, Katja Mertens-Scholz, Ludovit Skultety, Martin Pfeffer, Mathias W. Pletz
article en

Abstract

Although single peptides lacked discriminatory power, multi-epitope combinations reached acceptable accuracy and may be used as a complementary tool for commercial ELISAs. However, larger bioinformatic approaches and validation studies are required to identify specific peptides of high diagnostic accuracy.

Frontiers in MicrobiologyVol. 17
Friedrich-Loeffler-Institut (DE), University of Veterinary Medicine Vienna (AT), Czech Academy of Sciences, Institute of Microbiology (CZ), Biomedical Research Center of the Slovak Academy of Sciences (SK), Jena University Hospital (DE), Institute of Virology of the Slovak Academy of Sciences (SK)
Openalex Percentile: Top 50%
Vector-borne infectious diseases
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