Kappa free light chain index in CSF diagnostics: the impact of different immunoglobulin isotypes
Increase of κ-FLC index in patients with MS is predominantly due to an intrathecal IgG synthesis, while the contribution of intrathecal IgM is less frequent and quantitatively low.
Authors
- F. Deisenhammer
- Klaus Jun. Berek
- Harald Hegen
- Gabriel Bsteh (ORCID: https://orcid.org/0000-0002-0825-0851)
- Michael Auer (ORCID: https://orcid.org/0000-0002-5117-4225)
- Nik Krajnc (ORCID: https://orcid.org/0000-0002-4146-5870)
- Fabian Föttinger (ORCID: https://orcid.org/0009-0005-7970-5349)
- Janette F. Walde
- Franziska Di Pauli
- Martin Schmidauer
Institutions
- Innsbruck Medical University (AT)
- Universität Innsbruck (AT)
- Comprehensive Cancer Center Vienna (AT)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-17
- DOI
- https://doi.org/10.3389/fimmu.2026.1747659
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00