Persistence of Residual Insulin Secretion in Long-Standing Cystic Fibrosis-Related Diabetes
C-peptide levels in our cohort of PwCFRD were independent of diabetes duration, in contrast to PwT1D. A lower proinsulin-to-C-peptide ratio in PwCFRD compared to PwT1D suggested lower beta-cell dysfunction at fasting and stimulated evaluation. This supports the use of non-insulin therapies for adults with CFRD.
Authors
- Fidéline Bonnet-Serrano (ORCID: https://orcid.org/0000-0002-6628-8807)
- Irene Aguilera Garcia
- Florence Camus-Bablon
- François Mifsud
- Jennifer Nascimento da Silva
- Pierre-Régis Burgel
Institutions
- Université Paris Cité (FR)
- Hôpital Cochin (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- Endocrine Practice
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.eprac.2026.02.008
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00