Interaction between fluoride exposure and bone metabolism-related gene polymorphisms in the susceptibility to essential hypertension

This study suggests an association between fluoride exposure and hypertension, and indicates that bone metabolism-related genetic polymorphisms may modify this association. These findings provide novel insights into the gene-environment interplay in fluoride-induced hypertension and highlight potential targets for precision prevention.

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Publication Details

Journal
Ecotoxicology and Environmental Safety
Published
2026-02-01
DOI
https://doi.org/10.1016/j.ecoenv.2026.119903
Primary Topic
Fluoride Effects and Removal
Type
article
Field-Weighted Citation Impact
0.00
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article

Interaction between fluoride exposure and bone metabolism-related gene polymorphisms in the susceptibility to essential hypertension

Yanhui Gao, Shuaifei Yang, Xiaona Liu, Yanhui Gao et al.
Ecotoxicology and Environmental Safety
Fluoride Effects and Removal
article

Interaction between fluoride exposure and bone metabolism-related gene polymorphisms in the susceptibility to essential hypertension

Yanhui Gao, Shuaifei Yang, Xiaona Liu, Yanhui Gao, Yanmei Yang, Xin Wang, James Ogutu, Yue Lan Gao
article en

Abstract

This study suggests an association between fluoride exposure and hypertension, and indicates that bone metabolism-related genetic polymorphisms may modify this association. These findings provide novel insights into the gene-environment interplay in fluoride-induced hypertension and highlight potential targets for precision prevention.

Ecotoxicology and Environmental SafetyVol. 311
Guiyang Medical University (CN), Kenyatta University (KE), Harbin Medical University (CN)
Good health and well-being
Openalex Percentile: Top 56%
Fluoride Effects and Removal
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