Identification of plasma inflammatory biomarkers for Alzheimer’s disease reveals IFN-γ as a regulator of ACSL1-mediated microglia phenotype

These findings provide a new perspective on the involvement of plasma inflammatory markers for AD diagnosis, and suggest a novel link between IFN-γ and APOE ϵ4-associated AD risk through modulating the ACSL1-driven pathogenic LDAM phenotype.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-02-17
DOI
https://doi.org/10.3389/fimmu.2026.1770509
Primary Topic
Neuroinflammation and Neurodegeneration Mechanisms
Type
article
Field-Weighted Citation Impact
0.00

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article

Identification of plasma inflammatory biomarkers for Alzheimer’s disease reveals IFN-γ as a regulator of ACSL1-mediated microglia phenotype

C. F. Li, Zixian Lin, Bing-Biao Lin, Ronghua Huang et al.
Frontiers in Immunology
Neuroinflammation and Neurodegeneration Mechanisms
article

Identification of plasma inflammatory biomarkers for Alzheimer’s disease reveals IFN-γ as a regulator of ACSL1-mediated microglia phenotype

C. F. Li, Zixian Lin, Bing-Biao Lin, Ronghua Huang, Naili Wei, Jian Chen, Yingjie Zhang, Zhijie Lu, Yixuan Hao
article en

Abstract

These findings provide a new perspective on the involvement of plasma inflammatory markers for AD diagnosis, and suggest a novel link between IFN-γ and APOE ϵ4-associated AD risk through modulating the ACSL1-driven pathogenic LDAM phenotype.

Frontiers in ImmunologyVol. 17
Shantou University (CN), Cancer Hospital of Shantou University Medical College (CN), First Affiliated Hospital of Shantou University Medical College (CN), Zhujiang Hospital (CN), Women & Infants Hospital of Rhode Island (US)
Shantou University, China Postdoctoral Science Foundation, Shantou University Medical College, Basic and Applied Basic Research Foundation of Guangdong Province
Peace, Justice and strong institutions, Reduced inequalities
Openalex Percentile: Top 61%
Neuroinflammation and Neurodegeneration Mechanisms
DOIOpen Access PDFOpenAlex
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