Event-driven planning of two-armed trials with a binary endpoint
In settings with moderately low event probabilities, thinking in terms of the number of events instead of sample size may (1) facilitate the planning of clinical trials and help determine whether a trial is futile, and (2) lead to a simple event-driven design for binary endpoints that may be feasible and appealing.
Authors
- Raphaël Morsomme (ORCID: https://orcid.org/0000-0002-7421-6977)
- E BRITTAIN
Institutions
- National Institutes of Health (US)
- Office of Extramural Research (US)
Publication Details
- Journal
- Clinical Trials
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1177/17407745251415535
- Primary Topic
- Statistical Methods in Clinical Trials
- Type
- article
- Field-Weighted Citation Impact
- 0.00