Abstract PS2-03-18: Postoperative cavity remodeling technique in breast-conserving surgery: a case series

Abstract Background: Restoring breast contour in Oncoplastic Breast-Conserving Surgery (OBCS) with substantial glandular excision is challenging, as traditional implants or flaps are often invasive, costly, and carry risk of complications. We assessed the feasibility of postoperative cavity remodeling technique (PCRT) that promotes autologous tissue regeneration through mechanical stabilization of the lumpectomy cavity. Methods: This retrospective case series analyzed breast cancer patients with glandular defects ≥50% who underwent PCRT. The procedure involved intraoperative suture fixation of the residual cavity, and seroma-guided endogenous remodeling, supplemented by a mini dermal-fat fascial flap for incision reinforcement. Volume and resolution of postoperative serous effusion, incision-related complication, postoperative pain using visual analog scale (VAS), aesthetic evaluation (Harris score), and patient satisfaction (BREAST-Q) were assessed. Results: Among 60 patients included, 42 (70.0%) had moderate glandular defects (50%-69%) and 18 (30.0%) had severe defects (≥70%). Postoperative fluid accumulation peaked 1 week after drain removal, with 28.3% of patients requiring aspiration. Incision-related complications occurred in 10% of patients (wound dehiscence: 5.0%; suture-site reactions: 5.0%) at 3 months after drain removal, all cases were managed with supportive care. Moderate to severe pain (VAS score of 4-6 points) was reported in 73.3% of patients 1 week postoperatively, declining to 6.7% at 3 months. Aesthetic assessment was rated as good/excellent in 81.6% of patients, and 86.7% reported high satisfaction BREAST-Q score >80 while 78.3% reported very satisfied (Likert scale) at 12 months. Conclusions: PCRT might be a minimally invasive, implant-free reconstructive approach with favorable aesthetic and patient-reported outcomes in patients with significant breast tissue loss. Citation Format: Y. Chen, Y. Wang, X. Jiang, R. Huang, H. Liu. Postoperative cavity remodeling technique in breast-conserving surgery: a case series [abstract]. In: Proceedings of the San Antonio Breast Cancer Symposium 2025; 2025 Dec 9-12; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2026;32(4 Suppl):Abstract nr PS2-03-18.