LncRNA-PRLB drives ovarian cancer progression and chemoresistance by stabilizing GPX4 mRNA through the FUS-mediated suppression of ferroptosis
This study identifies lncRNA-PRLB as a critical upstream regulator of ferroptosis resistance and chemoresistance in ovarian cancer. By scaffolding FUS to stabilize GPX4 mRNA, lncRNA-PRLB maintains GPX4 expression and enables tumor cells to evade ferroptotic cell death.
Authors
- Na Li (ORCID: https://orcid.org/0000-0003-2811-4758)
- Yuzi Zhao
- Li Jiang
- Jing Cao
- Jie Pi
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- Wuhan Children's Hospital (CN)
- Dawu County People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-02-17
- DOI
- https://doi.org/10.3389/fmed.2026.1759058
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00