Antidepressant‐Associated Risk of Manic and Mixed Episode Hospitalization in Bipolar I Disorder: A 10‐Year Population‐Based Cohort Study
In BD-I, AD use increases manic/mixed episode hospitalization risk by approximately 30%, with differential effects across treatment strategies and patient subgroups. Combining ADs with mood stabilizers appears to mitigate this risk, while mixed episodes and younger age represent particularly high-risk scenarios. These findings support guideline recommendations against AD monotherapy while suggesting opportunities for personalized treatment approaches in BD-I.
Authors
- Marc Gadea Valentí
- G. Fico
- Vincenzo Oliva (ORCID: https://orcid.org/0000-0002-5961-6032)
- Jordi Blanch (ORCID: https://orcid.org/0000-0003-2597-8454)
- Marta Korniyenko (ORCID: https://orcid.org/0009-0006-0898-9265)
- M. de Prisco
- Gerard Anmella
- Ariadna Mas
- Allan H. Young
- Clàudia Valenzuela‐Pascual
- Eduard Vieta
- Diego Hidalgo‐Mazzei
Institutions
- King's College London (GB)
- Instituto de Salud Carlos III (ES)
- Hospital Clínic de Barcelona (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Medical Research Network (US)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Bipolar Disorders
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1111/bdi.70088
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerio de Ciencia, Innovación y Universidades
- Centres de Recerca de Catalunya
- European Commission
- Generalitat de Catalunya
- Sociedad Española de Psiquiatría Biológica
- Horizon 2020 Framework Programme
- Agència de Gestió d'Ajuts Universitaris i de Recerca
- Instituto de Salud Carlos III
- European Regional Development Fund
- Departament de Salut, Generalitat de Catalunya
- Agencia Estatal de Investigación
- European Social Fund
- Precursory Research for Embryonic Science and Technology
- EIT Health