Unlocking the secrets of gut microbiota: The untapped potential of Caenorhabditis elegans

This review first summarizes the shortcomings of current mammalian models in studying the interaction between gut microbiota and hosts. It also introduced a model for personalized, high-throughput research on gut microbiota in Caenorhabditis elegans. This model largely compensates for the current shortcomings of mammalian models and has great potential for application in the study of gut microbiota biological activity and its interaction mechanism with hosts.