Physicochemical stability of adenosine at a clinically relevant intracoronary dose to induce hyperaemia

Our findings support the prior preparation of adenosine for intracoronary administration in polypropylene syringes using 0.9% sodium chloride or 5% dextrose as diluents, with storage under tested conditions for up to 49 days. When required, the prepared syringes can be readily used during cardiac catheterisation. This approach would streamline workflow, minimise procedural delays and reduce the workload associated with on-site preparation.