Impaired clot formation and hemostasis in experimental traumatic hemorrhage model

This experimental study provides important aspects on coagulopathy and clot structure after traumatic hemorrhage including reduced thrombin generation and hyperfibrinolysis resulting in a more porous fibrin clot with lower density and thinner fibers. The methods used may be applied in the clinical research setting to gain further insights about hemostasis and clot formation for targeted therapy after traumatic hemorrhage.