The emerging role of complement inhibitory approaches in the treatment of acute sickle cell disease complications
Emerging preclinical and clinical data support the role of complement in SCD. Thorough and careful investigation of the efficacy and safety of proximal and distal complement inhibitors in SCD is warranted. This novel pathway has a tremendous potential to pave the way for innovative therapies to prevent and treat SCD complications.
Authors
- Akshaya Arjunan
- Michelle Long Schoettler (ORCID: https://orcid.org/0000-0003-4565-6399)
- Gabrielle Dean
- Satheesh Chonat (ORCID: https://orcid.org/0000-0002-5909-0800)
- Sara Graciaa
- Ronak Dave
- Maya Maarouf
- Haley Cowan
Institutions
- Emory University (US)
- Children's Healthcare of Atlanta (US)
Publication Details
- Journal
- Expert Review of Hematology
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1080/17474086.2026.2634277
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00