Comparative Efficacy of 4% Articaine with 1:1,00,000 Epinephrine Buccal Infiltration and 2% Lignocaine with 1:80,000 Epinephrine Inferior Alveolar Nerve Block in Patients with Irreversible Pulpitis: A Randomized Clinical Trial

which confers enhanced diffusibility.The low pKa increases the availability of uncharged base molecules for diffusion through the nerve sheath; as such, onset time is reduced.According to some authors, its ability to diffuse can produce pulpal anesthesia in mandibular teeth after infiltration anesthesia. [7][8]8][9] Studies have demonstrated that articaine and lignocaine, when administered as a buccal infiltration, can significantly enhance pulpal anesthesia,