PFKP binding AMOTL1 promotes tumor aerobic glycolysis and epithelial-mesenchymal transition by modulating Hippo pathway in head and neck cancer
PFKP remodels tumor metabolism and drives EMT in HNSCC <i>via</i> the AMOTL1/YAP/Hippo axis, highlighting its mechanistic and prognostic significance, and suggesting its potential as a future therapeutic target.
Authors
- Lingwa Wang
- Haiyang Li (ORCID: https://orcid.org/0000-0002-4935-9386)
- Yue Wang (ORCID: https://orcid.org/0000-0002-2818-9787)
- Ru Wang (ORCID: https://orcid.org/0000-0002-2768-1753)
- Qian Shi (ORCID: https://orcid.org/0000-0002-3777-1170)
- Ling Feng
- Jugao Fang
Institutions
- Beijing Tongren Hospital (CN)
Publication Details
- Journal
- Journal of Translational Internal Medicine
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1515/jtim-2026-0006
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00