Spontaneous Ecchymosis as Initial Presentation of Acquired Hemophilia A
Hemophilia A, a deficiency of clotting factor VIII, can be congenital, presenting with joint bleeding in childhood, or acquired, a rare subtype presenting as spontaneous bleeding most commonly seen in older adult patients. This report outlines an older adult patient with no history of bleeding disorders who developed acute-onset spontaneous ecchymoses and was found to have acquired hemophilia A. This case demonstrates the importance of a broad differential diagnosis in ecchymoses in older adult patients that includes coagulation factor deficiencies despite a lack of hematologic history. Early diagnosis and treatment of hemophilia A with hemostatic control and inhibitor eradication are imperative to prevent life-threatening bleeding.
Authors
- L. Ramagiri
- Julie Kielt
- Anna L. Farrell
Institutions
- The Ohio State University Wexner Medical Center (US)
- The Ohio State University (US)
Publication Details
- Journal
- Annals of Internal Medicine Clinical Cases
- Published
- 2026-02-01
- DOI
- https://doi.org/10.7326/aimcc.2025.1190
- Primary Topic
- Hemophilia Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00