Spontaneous Ecchymosis as Initial Presentation of Acquired Hemophilia A

Hemophilia A, a deficiency of clotting factor VIII, can be congenital, presenting with joint bleeding in childhood, or acquired, a rare subtype presenting as spontaneous bleeding most commonly seen in older adult patients. This report outlines an older adult patient with no history of bleeding disorders who developed acute-onset spontaneous ecchymoses and was found to have acquired hemophilia A. This case demonstrates the importance of a broad differential diagnosis in ecchymoses in older adult patients that includes coagulation factor deficiencies despite a lack of hematologic history. Early diagnosis and treatment of hemophilia A with hemostatic control and inhibitor eradication are imperative to prevent life-threatening bleeding.

Authors

Institutions

Publication Details

Journal
Annals of Internal Medicine Clinical Cases
Published
2026-02-01
DOI
https://doi.org/10.7326/aimcc.2025.1190
Primary Topic
Hemophilia Treatment and Research
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Spontaneous Ecchymosis as Initial Presentation of Acquired Hemophilia A

L. Ramagiri, Julie Kielt, Anna L. Farrell
Annals of Internal Medicine Clinical Cases
Hemophilia Treatment and Research
article

Spontaneous Ecchymosis as Initial Presentation of Acquired Hemophilia A

L. Ramagiri, Julie Kielt, Anna L. Farrell
article en

Abstract

Hemophilia A, a deficiency of clotting factor VIII, can be congenital, presenting with joint bleeding in childhood, or acquired, a rare subtype presenting as spontaneous bleeding most commonly seen in older adult patients. This report outlines an older adult patient with no history of bleeding disorders who developed acute-onset spontaneous ecchymoses and was found to have acquired hemophilia A. This case demonstrates the importance of a broad differential diagnosis in ecchymoses in older adult patients that includes coagulation factor deficiencies despite a lack of hematologic history. Early diagnosis and treatment of hemophilia A with hemostatic control and inhibitor eradication are imperative to prevent life-threatening bleeding.

Annals of Internal Medicine Clinical CasesVol. 5(2)
The Ohio State University Wexner Medical Center (US), The Ohio State University (US)
Zero hunger
Openalex Percentile: Top 51%
Hemophilia Treatment and Research
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Spontaneous Ecchymosis as Initial Presentation of Acquired Hemophilia A — L. Ramagiri, Julie Kielt, et al. · Annals of Internal Medicine Clinical Cases (2026) | TGRS Research Map | TGRS