A Significant Decline of Glomerular Filtration Rate in the Majority of Long‐Term Lithium Users: Results of a Dutch Prospective 10‐Year Cohort Study
This study provides further evidence that eGFR decline occurs in most long-term lithium users. Of this cohort, 59% of the participants had faster eGFR decline than the mean decline in the general population. Lithium exposure, quantified as mean serum lithium concentration, could be a contributing factor in this decline. eGFR trajectory was not altered by ceasing lithium.
Authors
- Joan Doornebal (ORCID: https://orcid.org/0000-0002-4671-8056)
- Tom Nijenhuis (ORCID: https://orcid.org/0000-0002-4375-7236)
- Debbie Zittema
- M. J. van der Aa
- E. M. Bisseling
- R. W. Kupka
- E. G. T. M. Hartong
- U. M. H. Klumpers
- J. Dammers
- A. P. M. Kerckhoffs
Institutions
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
- Amsterdam Neuroscience (NL)
- Radboud Institute for Molecular Life Sciences (NL)
- Canisius-Wilhelmina Ziekenhuis (NL)
- GGZ inGeest (NL)
- Isala (NL)
- Public Health Service of Amsterdam (NL)
- Amsterdam University Medical Centers (NL)
- Jeroen Bosch Ziekenhuis (NL)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Bipolar Disorders
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1111/bdi.70082
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00