Structural Basis for Trivalent Cross‐Linking of a Patient‐Derived <scp>IgE</scp> Antibody by the Major Peanut Allergen Ara h 2.0201
The trivalent binding is effective in forming large allergen-IgE complexes on mast cell or basophil surfaces and contributes to the potency of Ara h 2 in triggering allergic reactions and highlighting its role in anaphylaxis. Proline hydroxylation considerably enhances D08 binding affinity and contributes to cross-reactivity among Ara h 1-3 allergens.
Authors
- Tarja Parkkinen (ORCID: https://orcid.org/0000-0002-2348-0508)
- Juha Rouvinen
- Janne Jänis
- Heidi Heiniluoto
- Kristiina Takkinen
Institutions
- University of Eastern Finland (FI)
- Fortum (Finland) (FI)
Publication Details
- Journal
- Allergy
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1111/all.70258
- Primary Topic
- Food Allergy and Anaphylaxis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Itä-Suomen Yliopisto
- Biocenter Finland