Pharmacokinetic modelling as a tool to assess TB treatment adherence: application to the REMEMBER study

Poor adherence may have contributed to TB incidence in REMEMBER. While not definitive, personalised thresholds from model-based simulations remain useful for adherence assessment.

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Publication Details

Journal
IJTLD OPEN
Published
2026-02-01
DOI
https://doi.org/10.5588/ijtldopen.25.0467
Primary Topic
Tuberculosis Research and Epidemiology
Type
article
Field-Weighted Citation Impact
0.00
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article

Pharmacokinetic modelling as a tool to assess TB treatment adherence: application to the REMEMBER study

W.P. Samaneka, P. Severe, VG Veloso, M.C. Hosseinipour et al.
IJTLD OPEN
Tuberculosis Research and Epidemiology
article

Pharmacokinetic modelling as a tool to assess TB treatment adherence: application to the REMEMBER study

W.P. Samaneka, P. Severe, VG Veloso, M.C. Hosseinipour, J. Kumwenda, L. Mohapi, A. Naidoo, P. Denti, M. Nyirenda, A. Gupta, V. Mave, J. Valencia, N. Mwelase, M. Chirehwa, C. Kanyama, N. Abdelgawad, K. Scarsi, H. McIlleron
article en

Abstract

Poor adherence may have contributed to TB incidence in REMEMBER. While not definitive, personalised thresholds from model-based simulations remain useful for adherence assessment.

IJTLD OPENVol. 3(2)
University of North Carolina at Chapel Hill (US), Nebraska Medical Center (US), Johns Hopkins University (US), University of Zimbabwe (ZW), University of Cape Town (ZA), University of the Witwatersrand (ZA), Asociación Civil Impacta Salud y Educación (PE), Johns Hopkins Medicine (US), Centre for the AIDS Programme of Research in South Africa (ZA), Kamuzu Central Hospital (MW), Instituto Evandro Chagas (BR), Perinatal HIV Research Unit (ZA), Government Medical College (IN), Kamuzu University of Health Sciences (MW), Fundação Oswaldo Cruz (BR), University of Nebraska Medical Center (US)
Good health and well-being
Openalex Percentile: Top 52%
Tuberculosis Research and Epidemiology
DOIOpen Access PDFOpenAlex
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Pharmacokinetic modelling as a tool to assess TB treatment adherence: application to the REMEMBER study — W.P. Samaneka, P. Severe, et al. · IJTLD OPEN (2026) | TGRS Research Map | TGRS