Early growth response 2 as a target of IL-13/STAT6 signaling induces the goblet cell metaplasia of allergic airway epithelia

Together, upregulation of EGR2 expression in allergic airway epithelia contributes to the goblet cell metaplasia and mucous hypersecretion, and intervention of EGR2 is thus a promising approach in the therapy of the cardinal feature of asthma.

Authors

Institutions

Publication Details

Journal
Allergology International
Published
2026-02-17
DOI
https://doi.org/10.1016/j.alit.2026.01.002
Primary Topic
Asthma and respiratory diseases
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Early growth response 2 as a target of IL-13/STAT6 signaling induces the goblet cell metaplasia of allergic airway epithelia

Chengyun Xu, Meiping Lu, Yuqing Cai, Yangyun He et al.
Allergology International
Asthma and respiratory diseases
article

Early growth response 2 as a target of IL-13/STAT6 signaling induces the goblet cell metaplasia of allergic airway epithelia

Chengyun Xu, Meiping Lu, Yuqing Cai, Yangyun He, Dan Tan, Qihang Chen, Min Zhou, Liyin Zhu, Ximei Wu, Yuanyuan Yang
article en

Abstract

Together, upregulation of EGR2 expression in allergic airway epithelia contributes to the goblet cell metaplasia and mucous hypersecretion, and intervention of EGR2 is thus a promising approach in the therapy of the cardinal feature of asthma.

Allergology InternationalVol. 75(2)
Sir Run Run Shaw Hospital (CN), Children's Hospital of Zhejiang University (CN), Zhejiang Lab (CN), Zhejiang Shuren University (CN), Women's Hospital, School of Medicine, Zhejiang University (CN), Communication University of Zhejiang (CN), Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN), Zhejiang University (CN)
Good health and well-being
Openalex Percentile: Top 51%
Asthma and respiratory diseases
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Early growth response 2 as a target of IL-13/STAT6 signaling induces the goblet cell metaplasia of allergic airway epithelia — Chengyun Xu, Meiping Lu, et al. · Allergology International (2026) | TGRS Research Map | TGRS