Coordinated DNA methyltransferase 3A and methyltransferase-like 7A activity reprograms the tumor microenvironment through discoidin domain receptor 1 signaling
DNMT3A and METTL7A were shown to cooperatively regulate <i>DDR1</i> <i>via</i> DNA/m6A methylation, which drives Treg-mediated immune suppression and recurrence. This study provided novel insights and therapeutic targets for breast cancer prognosis and treatment.
Authors
- Yaobang Liu
- Dan Yang
- Zhengyang Bai
- Bin Lian
- Jinping Li
- Jiayi Li
Institutions
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
Publication Details
- Journal
- Cancer Biology and Medicine
- Published
- 2026-02-16
- DOI
- https://doi.org/10.20892/j.issn.2095-3941.2025.0261
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00