Effectiveness of bivalent BA.1 mRNA booster vaccines during the autumn 2022 COVID-19 booster programme in adults aged 50+ in England: observational matched cohort study using OpenSAFELY

Rates of COVID-19-related hospitalisation and death were substantially lower after bivalent original/omicron BA.1 mRNA booster vaccine than in people who remained unboosted. Apparent protection against fracture suggests some unmeasured confounding. Outcomes appeared similar for the Moderna and Pfizer-BioNTech vaccines.

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Publication Details

Journal
Vaccine
Published
2026-02-18
DOI
https://doi.org/10.1016/j.vaccine.2026.128276
Primary Topic
SARS-CoV-2 and COVID-19 Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Effectiveness of bivalent BA.1 mRNA booster vaccines during the autumn 2022 COVID-19 booster programme in adults aged 50+ in England: observational matched cohort study using OpenSAFELY

Rachel Denholm, Paul Madley‐Dowd, Jonathan A.C. Sterne, Tom M. Palmer et al.
Vaccine
SARS-CoV-2 and COVID-19 Research
article

Effectiveness of bivalent BA.1 mRNA booster vaccines during the autumn 2022 COVID-19 booster programme in adults aged 50+ in England: observational matched cohort study using OpenSAFELY

Rachel Denholm, Paul Madley‐Dowd, Jonathan A.C. Sterne, Tom M. Palmer, Elsie M.F. Horne, Venexia Walker
article en

Abstract

Rates of COVID-19-related hospitalisation and death were substantially lower after bivalent original/omicron BA.1 mRNA booster vaccine than in people who remained unboosted. Apparent protection against fracture suggests some unmeasured confounding. Outcomes appeared similar for the Moderna and Pfizer-BioNTech vaccines.

VaccineVol. 76
University Hospitals Bristol NHS Foundation Trust (GB), Bristol City Council (GB), University of Bristol (GB), University of Oxford (GB), NIHR Bristol Biomedical Research Centre (GB)
Good health and well-being
Openalex Percentile: Top 52%
SARS-CoV-2 and COVID-19 Research
DOIOpen Access PDFOpenAlex
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Effectiveness of bivalent BA.1 mRNA booster vaccines during the autumn 2022 COVID-19 booster programme in adults aged 50+ in England: observational matched cohort study using OpenSAFELY — Rachel Denholm, Paul Madley‐Dowd, et al. · Vaccine (2026) | TGRS Research Map | TGRS