Unraveling the root causes of HIV-1 persistence

HIV-1 persists through a multilayered network in which viral latency, clonal proliferation, cell-intrinsic survival and immune-evasion programs, and the biology of tissue sanctuaries act in concert to sustain the viral reservoir. This interconnected architecture-rather than any single mechanism-constitutes the fundamental basis of HIV-1 persistence.

Authors

Mathias Lichterfeld
Weiwei Sun

Institutions

Brigham and Women's Hospital (US)
Ragon Institute of MGH, MIT and Harvard (US)

Publication Details

Journal: Current Opinion in HIV and AIDS
Published: 2026-02-17
DOI: https://doi.org/10.1097/coh.0000000000001022
Primary Topic: HIV Research and Treatment
Type: article
Field-Weighted Citation Impact: 0.00

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article

Unraveling the root causes of HIV-1 persistence

Mathias Lichterfeld, Weiwei Sun

Feb 17, 2026

Current Opinion in HIV and AIDS

HIV Research and Treatment

article

Unraveling the root causes of HIV-1 persistence

Mathias Lichterfeld, Weiwei Sun

February 17, 2026article en

Abstract

Current Opinion in HIV and AIDS

Brigham and Women's Hospital (US), Ragon Institute of MGH, MIT and Harvard (US)

Openalex Percentile: Top 55%

HIV Research and Treatment

DOI Source OpenAlex

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Unraveling the root causes of HIV-1 persistence — Mathias Lichterfeld, Weiwei Sun · Current Opinion in HIV and AIDS (2026) | TGRS Research Map | TGRS